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X-ORIGINAL-URL:https://www.lps.u-psud.fr/
X-WR-CALNAME:Laboratoire de physique des Solides
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BEGIN:VEVENT
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DTSTART;TZID=Europe/Paris:20221209T110000
DTEND;TZID=Europe/Paris:20221209T120000
DTSTAMP:20221013T142900
UID:MEC-f51238cd02c93b89d8fbee5667d077fc@lps.u-psud.fr
CREATED:20221013
LAST-MODIFIED:20221124
PRIORITY:5
TRANSP:OPAQUE
SUMMARY:Doron Grossman – Instabilities and Geometry of Growing Tissues
DESCRIPTION:\nCollege – de – France  (for this work); LadHyX, Ecole polytechnique (current).\n\n\n\nWe present a covariant continuum formulation of a generalized two-dimensional vertexlike modelof epithelial tissues which describes tissues with different underlying geometries, and allows for ananalytical macroscopic description. Using a geometrical approach and out-of-equilibriumstatistical mechanics, we calculate both mechanical and dynamical instabilities of a tissue, andtheir dependences on various variables, including activity, and cell-shape heterogeneity (disorder).We show how both plastic cellular rearrangements and the tissue elastic response depend on theexistence of mechanical residual stresses at the cellular level. Even freely growing tissues mayexhibit a growth instability depending on the intrinsic proliferation rate. Our main result is anexplicit calculation of the cell pressure in a homeostatic state of a confined growing tissue. Weshow that the homeostatic pressure can be negative and depends on the existence of mechanicalresidual stresses. This geometric model allows us to sort out elastic and plastic effects in a growing,flowing, tissue.\n
URL:https://www.lps.u-psud.fr/events/doron-grossman/
CATEGORIES:Séminaire Matière Molle Phys-Bio
LOCATION:Orsay
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