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X-WR-CALNAME:Laboratoire de physique des Solides
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DTSTART;TZID=Europe/Paris:20230421T110000
DTEND;TZID=Europe/Paris:20230421T120000
DTSTAMP:20230404T132200
UID:MEC-c793b3be8f18731f2a4c627fb3c6c63d@lps.u-psud.fr
CREATED:20230404
LAST-MODIFIED:20230404
PRIORITY:5
TRANSP:OPAQUE
SUMMARY:Collective effects in epithelial cell elimination – Romain LEVAYER
DESCRIPTION:\n Department of Developmental and Stem Cell Biology, Institut Pasteur, Paris, France\n\n\n\nAbstract: While the signals regulating apoptosis during development are rather well known, what sets the precise spatio-temporal distribution of cell death and the adjustment of cell elimination to local perturbations is not well understood. Similarly, how cells eventually engage in apoptosis and how the removal of cells from epithelial layer is orchestrated through cell extrusion remained poorly understood, especially in vivo. In this seminar, I will illustrate the multi-layered regulation of cell death through three examples, the first one describing the impact of mechanical stress on cell elimination, the second one on local feedbacks that can fine tune the distribution of cell elimination in space and time revealing interesting self-organising properties, and the last one focusing on the engagement in apoptosis and the coordination of cell extrusion by caspases. Altogether, I will propose a roadmap to build a more predictive understanding of cell death in vivo that can directly impact tissue homeostasis, morphogenesis, growth and clonal selection.\n
URL:https://www.lps.u-psud.fr/en/events/collective-effects-in-epithelial-cell-elimination-romain-levayer/
CATEGORIES:Soft matter and Phys-Bio seminar
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