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X-ORIGINAL-URL:https://www.lps.u-psud.fr/
X-WR-CALNAME:Laboratoire de physique des Solides
X-WR-CALDESC:
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BEGIN:VEVENT
CLASS:PUBLIC
DTSTART;TZID=Europe/Paris:20251017T110000
DTEND;TZID=Europe/Paris:20251017T120000
DTSTAMP:20250911T085600
UID:MEC-f4e3ce3e7b581ff32e40968298ba013d@lps.u-psud.fr
CREATED:20250911
LAST-MODIFIED:20251016
PRIORITY:5
TRANSP:OPAQUE
SUMMARY:Séminaire Phys/Bio: Dennis Wörthmüller (Institut Curie)
DESCRIPTION:\nLocation: FAST/LPTMS seminar room, building 530\n\n\n\nWhen Actin Meets Curvature: Modeling Free-Standing Cell Protrusions\n\n\n\nCell shape changes are largely controlled by the actin cytoskeleton, a dynamic filament network beneath the plasma membrane. Some cell types can form extended free-standing protrusions that are not supported by an extracellular substrate, and whose initiation is thought to rely on proteins that modulate actin dynamics through sensitivity to membrane curvature. I will present a theoretical model for a free-standing viscous actin network growing on a corrugated membrane, which couples active-gel mechanics, membrane deformation, and the recruitment of curvature-sensitive actin nucleators. The model shows that uniform actin polymerization stabilizes membrane shape, whereas curvature-dependent nucleation can render the membrane linearly unstable and drive spontaneous deformations with a well-defined wavelength that could initiate protrusions. To explore these processes beyond the linear regime, we develop a finite-element framework that captures nonlinear deformations of fluid and elastic layers, opening the way to realistic simulations of actin-driven membrane shape changes.\n
URL:https://www.lps.u-psud.fr/events/seminaire-phys-bio-dennis-worthmuller/
CATEGORIES:Séminaire Matière Molle Phys-Bio
LOCATION:LPTMS
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