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Calcium oxalate stones developed from a carbapatite Randall’s plaques


Calcium oxalate stones developed from a carbapatite Randall's plaques

Typical heterogeneous nucleation is commonly observed in the case of calcium oxalate stones developed from a carbapatite Randall’s plaque.

 

 

This particular deposit is located at the surface of attached kidney stones and serves as nucleus. This structural particularity as well as other major public health problems such diabetes type 2 may explain a dramatic increase of urolithiasis now affecting up to 20% of the population in the industrialized countries. Regarding the chemical composition, even if other phosphate phases can be found such as whitlockite or brushite, calcium phosphate apatite (CA).

 

Contact : D. Bazin (bazin@lps.u-psud.fr)

 

Reference:

X. Carpentier, D. Bazin, P. Jungers, S. Reguer, D. Thiaudière and M. Daudon, The pathogenesis of Randall’s plaque: a papilla cartography of Ca compounds through an ex vivo investigation based on XANES spectroscopy, J. Synchrotron Rad. (2010). 17, 374-379 [ doi:10.1107/S0909049510003791 ]