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Séminaire d’Andre Estevez-Torres

Engineering reaction networks outside the cell : reactions and reactors


Andre Estevez-Torres

Laboratoire de Photonique et de Nanostructures

Engineering reaction networks outside the cell : reactions and reactors

Reaction networks with well-defined dynamics and topology are fundamental elements in the emergence of complex biological behaviors such as gene regulation, chemotaxis, or embryo development. With the tools of synthetic biology we start to understand how to engineer those networks inside the cell. We know, however, very little about how to implement them outside the cell.

I will describe our ongoing efforts towards the engineering of such networks in vitro. First, I will attempt to give a chemist’s point of view of the network description used in systems biology. Second, I will introduce the toolboxes that I think we need for engineering reaction networks with interesting functions outside the cell. Namely, a controllable set of reactions and a tunable reactor. Finally, I will show recent results obtained in a joint effort with Jean-Christophe Galas to develop a nanoliter-scale continuous reactor for studying oscillatory reactions.