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Research activities


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We are interested in self assembly properties of biological macromolecules and living cells, principally bacteria. These are complex systems characterized by their soft matter and polyelectrolyte properties.
Three main topics are currently being developped :
- Self assembly in condensed DNA and chromatin in vitro and in vivo
- Self-assembly and disassembly of viruses and viromimetic nanoparticles
- Collective behaviour of bacteria

 

CONDENSED DNA & CHROMATIN


VIROMIMETIC NANOPARTICLES


BACTERIA AND BIOFILMS


 

We develop the methods necessary :

  • to follow the dynamics of our systems (time-resolved SAXS, light scattering, fluorescence microscopy)
  • to visualize individual molecules and nano-objects in native conditions (cryo-electron microscopy)
  • to image cells and hydrated dense materials at high resolution by freeze-fracture and cryo-electron microscopy of vitreous sections (CEMOVIS)

 

IMAGING THE CELL AT HIGH RESOLUTION


CYO-ELECTRON MICROSCOPY


TIME-RESOLVED SAXS


MICROFLUIDICS


We also take advantage of fruitful collaborations and the large-scale facilities available in the vicinity of Orsay to explore the soft matter at the nanoscale :

  • Laboratoire Léon Brillouin (Saclay) : small-angle neutron scattering on the PACE beamline.
  • Soleil synchrotron (Gif-sur-Yvette) : small-angle x-ray scattering on the SWING beamline.