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Bubbles and antibubbles for ultrasound-guided drug delivery - Michiel Postema

INSERM, Université de Tours

Antibubbles are gas bubbles containing a liquid droplet core and, typically, a stabilising outer shell. It has been hypothesised that acoustically driven antibubbles can be used for active leakage detection from subsea production facilities. Our study treats the dynamics of spherically symmetric microscopic antibubbles, building on existing models of bubble dynamics. A more complete understanding of microbubble dynamics demands that the effects of the translational dynamics is included into the Rayleigh-Plesset equation. Moreover, it has been a goal to derive a theory that is not based on ad-hoc parameters due to the presence of a shell, but rather on material properties.
Such antibubbles can be utilized in ultrasound-guided drug delivery, similar to coated microbubbles. The dynamic behavior of both is compared, making use of high-speed photography footage.
In addition, the first patient studies using microbubble-and-drug combinations are briefly presented, for the treatment of pancreatic cancer.


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